Questão 20 - Prova Geral Medicina - PUC Campinas 2026

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Poor sleep linked to 172 diseases, including dementia, Parkinson’s, diabetes

By Corrie Pelc on
August 4, 2025

   Researchers have found a link between sleep quality and disease risk with many chronic conditions.
   Getting enough quality sleep every night is important for good health. However, some people may still be unclear about what “quality sleep” entails and what impact sleep really has on their health.
   “[Until] now we have not completely understood how sleep builds our health,” Qing Chen, PhD, associate professor at the College of Preventive Medicine at the Third Military Medical University in China, told Medical News Today.
  “Maybe we only know that sleep deprivation is harmful. No scientist has 100% confidence to tell us when we should sleep or when we should not sleep, [or] whether there are additional sleep tips that are important for health,“ said Chen. “This is not enough to make a really healthy sleep schedule.”
    For this study, researchers analyzed medical data from more than 88,000 adults in the UK Biobank database to measure both their sleep traits and disease diagnoses.
    After an average 7-year follow-up, researchers associated 172 diseases with poor sleep patterns, including irregular bedtimes and off-circadian rhythms. The 24-hour sleep-wake cycle is one of the most widely recognized circadian rhythms. Humans tend to become tired at night and feel more awake during the day.
   Of these 172 diseases, the risk for 42 diseases was at least doubled, including age-related physical debility, gangrene, fibrosis, and cirrhosis of the liver.
   Chen and his team also discovered that 92 of the 172 diseases had more than 20% of their risk traceable to poor sleep, including dementia, primary hypertension, Parkinson’s disease, type 2 diabetes, and acute kidney failure.
   Daniel Truong, MD, a neurologist and medical director of the Truong Neuroscience Institute in Fountain Valley, CA, who was not involved in the recent study, told MNT that his reaction to this study’s findings was one of surprising clarity: Sleep regularity matters more than sleep duration in explaining disease risk.
   “It is crucial for researchers to continue investigating how sleep affects overall health because sleep is a foundational biological process that influences nearly every organ system 􀀐 and yet it remains one of the most underappreciated and misunderstood contributors to disease risk and health maintenance,” Truong continued.
   “This recent study underscores why this research must continue. __I__ genetic predispositions or aging, sleep habits can be changed. Sleep affects multiple biological systems such as [the] immune system, endocrine, cardiovascular, [and] neurological problems,” he said.
   Katie S. McCullar, PhD, a fellow at Massachusetts General Hospital and Harvard Medical School, told MNT that this research reinforces the idea that sleep is not just a passive state but a vital process that supports nearly every aspect of health, and adds to a
growing body of research that demonstrates that healthy sleep is one of the foundational determinants of health.

(Disponível em: https://www.medicalnews today.com. Adapted)

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